Synthetic Route of 58483-95-7 , The common heterocyclic compound, 58483-95-7, name is 5-Amino-2-chloropyridine-4-carboxylic acid, molecular formula is C6H5ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
6-Chloro-3H-pyrido[3,4-d]pyrimidin-4-one. A solution of 5-amino-2-chloropyridine-4-carboxylic acid (8.1 g, 4.7 mmol) in formamide (100 mL) is stirred at 140° C. for 12 h. Dilution of the cooled mixture with water gives a precipitate of 6-chloro-3H-pyrido[3,4-d]pyrimidin-4-one (7.3 g, 86percent yield). 1 H NMR (DMSO) delta 12.73 (1H, m), 8.90 (1H, d, J=0.7 Hz), 8.23 (1H, s), 7.97 (1H, d, J=0.7 Hz).
The synthetic route of 58483-95-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Warner-Lambert Company; US5654307; (1997); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem