Adding a certain compound to certain chemical reactions, such as: 16133-25-8, Pyridine-3-sulfonyl chloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 16133-25-8, blongs to pyridine-derivatives compound. Recommanded Product: 16133-25-8
Reference Example 23; tert-butyl { [5-bromo-l- (pyridin-3-ylsulfonyl) -lH-pyrrol-3- yl]methyl }methylcarbamate; To a suspension of sodium hydride (60percent in oil, 7.4 g) in tetrahydrofuran (300 mL) was added a solution of tert-butyl [ (5-bromo-lH-pyrrol-3-yl) methyl]methylcarbamate (44.5 g) in tetrahydrofuran (60 mL) at 0°C, and 15-crown-5 (40.7 g) and pyridine-3-sulfonyl chloride (30.1 g) were added at the same temperature. The mixture was stirred at room temperature for 30 min, water was added and the mixture was concentrated under reduced pressure. The residue was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was washed with a mixed solvent of diisopropyl ether-hexane=l : 1 to give the title compound as colorless crystals (yield 45.2 g, 68percent) . 1H-NMR (CDCl3) delta: 1.47(9H,s), 2.80 (3H,brs) , 4.18 (2H,brs) ,6.28(lH,brs) , 7.35 (lH,brs) , 7.48-7.52 (IH,m) , 8.18-8.22 (lH,m) , 8.85-8.88 ( IH,m), 9.12-9.13 (IH, m) .
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16133-25-8, its application will become more common.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2008/108380; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem