Synthetic Route of 5315-25-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 5315-25-3 as follows.
General procedure: A dried round bottomed flask equipped with a magnetic stirring bar was charged with 10mg Polymer anchored-Pd(II) D catalyst (PS-NPPZ-Pd) (0.0045mmol/Pd), 2-halopyridine (0.5mmol), phenylboronic acid (0.6mmol) and K3PO4 (1.0mmol) were added to a reaction vessel. The mixture was stirred in 4mL of H2O: EtOH (1:1) at 100C for 8h and then cooled to room temperature. The catalyst was filtered and the filtrate was extracted with ethyl acetate (3×10mL). The combined organic layers were extracted with water, and dried over anhydrous Na2SO4. The organic layers were evaporated under reduced pressure and the resulting crude product was purified by column chromatography by using ethyl acetate/hexane (10:90) as eluent to give the corresponding coupled products. The products were characterized by 1H NMR, 13C NMR and HRMS analysis.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5315-25-3, its application will become more common.
Reference:
Article; Perumgani, Pullaiah C.; Kodicherla, Balaswamy; Mandapati, Mohan Rao; Parvathaneni, Sai Prathima; Inorganica Chimica Acta; vol. 477; (2018); p. 227 – 232;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem