Synthetic Route of 1034667-22-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1034667-22-5, name is 5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows.
Formation of 3-bromo-5-fluoro-lH-pyrazolo[3,4-A]pyridine (4)To the miture of 5-fluoro-lH-pyrazolo[3,4-6]pyridin-3-amine, 3, (0.88 g, 5.79 mmol) in bromoform (8.8 mL) was added ter/-butyl nitrite ( 1.38 mL, 1 1.57 mmol). This mixture was heated to 61 C for 1 h and then heated to 90 C for an additional hour. The mixture was cooled to room temperature and bromoform was removed under reduced pressure. The resulting crude residue was purified by silica gel chromatography (5-50% ethyl acetate/hexanes) to afford 970 mg of the desired product as a white solid: NMR (300 MHz, DMSO) delta 14.22 (s, 1 H), 8.67 (dd, J = 2.7, 1.9 Hz, 1 H), 8.07 (dd, J = 8.2, 2.7 Hz, 1 H); LC/MS Gradient 10-90%, 0.1 % formic 5min, C 18/ACN, Retention Time = 2.42 min, (M+H) 216.1 1.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1034667-22-5, 5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; CHARIFSON, Paul, S.; CLARK, Michael, P.; BANDARAGE, Upul, K.; DAVIES, Ioana; DUFFY, John, P.; GAO, Huai; FENG, Jun; LIANG, Jianglin; KENNEDY, Joseph, M.; LEDEBOER, Mark, W.; LEDFORD, Brian; MALTAIS, Francois; PEROLA, Emanuele; WO2012/83117; (2012); A1;,
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