Application of 6937-03-7, Adding some certain compound to certain chemical reactions, such as: 6937-03-7, name is Methyl 2-aminoisonicotinate,molecular formula is C7H8N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6937-03-7.
To a mixture of compound 69.10 (60 g, 394.35 mmol, 1 eq) and DMAP (2.41 g,19.72 mmol, 0.05 eq) in t-BuOH (600 mL) and ACETONE (200 mL) was added Boc20(344.26 g, 1.58 mol, 362.38 mL, 4 eq) dropwise at 18C underN2. The mixture was stirred at 18 C for 15 hours. The solution was diluted with pentane (200 mL), cooled in the refrigerator for 3 hours and filtered to obtain compound 69.9 (42 g, 166.5 mmol, 42% yield) as a white solid. ?H NMR (400 MHz, DMSO-d6) & 1.38 – 1.54 (m, 9 H), 3.82-3.96 (m, 3 H),7.44 (dd, J5.07, 1.41 Hz, 1 H), 8.32 (s, 1 H), 8.42 (d, J5.14 Hz, 1 H) and 10.11 (s, 1 H) ppm.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6937-03-7, Methyl 2-aminoisonicotinate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CORTEXYME, INC.; LYNCH, Casey C.; KONRADI, Andrei; GALEMMO, JR., Robert A.; (218 pag.)WO2018/209132; (2018); A1;,
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