With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.20265-38-7, name is 2-Methoxypyridin-3-amine, molecular formula is C6H8N2O, molecular weight is 124.14, as common compound, the synthetic route is as follows.Quality Control of 2-Methoxypyridin-3-amine
Step 1-Synthesis of 6-chloro-N-(2-methoxypyridin-3-yl)pyrimidin-4-amineTo a solution of 4,6-dichloropyrimidine (660.04 mg, 4.43 mmol) in 1-butanol (10 mL) was added DIPEA (0.67 ml, 4.03 mmol) followed by 2-methoxypyridin-3-amine (500 mg, 4.03 mmol).The reaction mixture was then heated to 90° C. for 2 hr.The reaction mixture was then concentrated in vacuo and partitioned between DCM and water.A precipitate was removed by filtration and the organics extracted (2*20 ml DCM).The combined organic extracts were then washed with 0.5M HCl (5 ml) and then dried (Na2SO4), filtered and concentrated in vacuo to give the title intermediate (300 mg, LC-MS purity=83percent); LC-MS: m/z=+236.95/238.90 (M+H)+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,20265-38-7, 2-Methoxypyridin-3-amine, and friends who are interested can also refer to it.
Reference:
Patent; Genentech, Inc.; US2012/214762; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem