Synthetic Route of 61889-48-3, Adding some certain compound to certain chemical reactions, such as: 61889-48-3, name is 2-Chloro-1-(pyridin-3-yl)ethanone hydrochloride,molecular formula is C7H7Cl2NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 61889-48-3.
Recombinant E. coli HB101 (pNTS1G) accession number FERM BP-5835 (February 24, 1997, International Patent Organism Depositary, National Institute of Advanced Industrial Science and Technology, address: AIST Tsukuba Central 6, 1-1, Higashi 1-Chome, Tsukuba-shi, Ibaraki-ken 305-8566 Japan) was inoculated in 50 ml of 2xYT medium (tryptone 16 g, yeast extract 10 g, sodium chloride 5 g, water 1 L, pH before sterilization 7.0), which was sterilized in a 500 ml Sakaguchi flask, and cultured ‘by shaking at 37C for 18 hours. After 40 mg of NADP+ and 56.1 g of glucose were added to 800 ml of the obtained culture solution, 40 g of 3-(2-chloro-acetyl)pyridine hydrochloride was added over 5 hours while adjusting the pH to 6.5 at 30C and then agitation was conducted for 2 hours. After the reaction was finished, the reaction solution was extracted by ethyl acetate and concentrated under reduced pressure, to obtain a 31.4 g of yellow oily matter, which is the title compound. The chemical purity and optical purity were analyzed in the same manner as in Example 1. The chemical purity was 97.8 % and the optical purity was 99.8 %ee.1H-NMR (D2O,400MHz/ppm); 3.62 (2H,bs), 4.66 (2H,s), 5.88 (1H,s)
According to the analysis of related databases, 61889-48-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; KANEKA CORPORATION; EP1454899; (2004); A1;,
Pyridine – Wikipedia,
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