Reference of 39977-44-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.39977-44-1, name is Methyl 6-(hydroxymethyl)picolinate, molecular formula is C8H9NO3, molecular weight is 167.16, as common compound, the synthetic route is as follows.
Compound 2 (661 mg, 3.95 mmol) and 2-iodoxybenzoic (IBX 2.77 g, 9.89 mmol) were stirred in ethyl acetate (50 mL) at 80 C for 3 h. When the reaction was completed, the solid was removed by filtration. The organic phases were evaporated to dryness to give white powder-like solid 9 (640 mg). yield: 98%. 1H NMR (400 MHz, CDCl3) delta 10.20 (s, 1H), 8.36 (dd, J 7.7, 1.1 Hz, 1H), 8.16 (dd, J 7.7,1.1 Hz, 1H), 8.06 (t, J 7.7 Hz, 1H), 4.07 (s, 3H).
The chemical industry reduces the impact on the environment during synthesis 39977-44-1, I believe this compound will play a more active role in future production and life.
Reference:
Article; Shi, Xiu-Fang; Wang, Ming-Ming; Huang, Shu-chao; Han, Jiang-Xue; Chu, Wen-Chao; Xiao, Chunling; Zhang, En; Qin, Shangshang; European Journal of Medicinal Chemistry; vol. 167; (2019); p. 367 – 376;,
Pyridine – Wikipedia,
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