Electric Literature of 60032-57-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 60032-57-7, name is 2-Methylnicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows.
(b) methyl 2-Q -(hydroxy(2-methyipyridin-3-yl)mnethyi)bcnzofuran-5-yl)acctate: To asohLtion of methyl 2-(Z-bromobenzofuran-5-yi)acctate (0.35 g, 1.3 mmol) in dry THE (5 niL) wasadded i-PrMgCI-iithium chloride (1.3 M solution in THF, 1.3 mL, 1.6 nnol) dropwise at 0 C andthe reaction mixture was stilTed for 30 mm maintaining the same temperature. ?To the reaction mixture was added a solution of 2-methylnicotinaldehyde (157 rng, 1.3 mniol) in dry TF1F (5 mL) and the reaction mixture was further stirred for 2 h at 0 C. The reaction mixture was quenched with saturated NH4C1 solution and the organic product was extracted with EtOAc. The organic layer was dried over anhydrous Na2SO4 and the solvent was removed under vacuum. The crudeproduct was purified by column chromatography (neutral alumina, eluent 5-10% MeOI-f in CH2C12) to afford the title compound (160 mg, yield 40%) as a yellow viscous liquid. ?H NMR (300 MHz, MeOH-d,) 6 ppm 8.36 – 8.34 (dd, J= 4.9 Hz, 1.6 Hz, IH), 8.01 – 7.97 (dd, J= 7.9 Hz, 1.5 Hz, 1H), 7.447.43 (d,J 1.3 Ffz, 1Ff), 7.37-7.30 (in, 2Ff), 7.18 -7.14 (dd,J 8.4 Ffz, 1.6 Ffz, 1Ff), 6.56 (s, 1ff), 6.08 (s, 1Ff), 3.69 (s, 2Ff), 3.65 (s, 3Ff), 2.52 (s, 3Ff).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 60032-57-7, 2-Methylnicotinaldehyde.
Reference:
Patent; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; WO2013/19626; (2013); A1;,
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