Synthetic Route of 60032-57-7 ,Some common heterocyclic compound, 60032-57-7, molecular formula is C7H7NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: 4-Chlorophenylmagnesium bromide (1.0 M in Et2O; 11.0 mL, 11.0 mmol) was added dropwise to a stirred solution of 2-chloronicotinaldehyde 2b (1.42 g, 10.0 mmol) in dry THF (50 mL) under a nitrogen atmosphere at ambient temperature. After 30 minutes, the reaction was quenched by the addition of saturated ammonium chloride (aq; 100 mL). The product was extracted with EtOAc (2 × 100 mL) and the extracts washed with brine (100 mL), combined and dried (MgSO4). The crude product was recrystallised from hot 5% EtOAc-hexane to give the alcohol 5a (1.99 g, 78%) as a white crystalline solid, mp 102 – 103 C. Identical in all other ways to that described above (General Procedure C).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,60032-57-7, its application will become more common.
Reference:
Article; Roughley, Stephen D.; Browne, Helen; MacIas, Alba T.; Benwell, Karen; Brooks, Teresa; D’Alessandro, Jalanie; Daniels, Zoe; Dugdale, Sarah; Francis, Geraint; Gibbons, Ben; Hart, Terance; Haymes, Timothy; Kennett, Guy; Lightowler, Sean; Matassova, Natalia; Mansell, Howard; Merrett, Angela; Misra, Anil; Padfield, Anthony; Parsons, Rachel; Pratt, Robert; Robertson, Alan; Simmonite, Heather; Tan, Kiri; Walls, Steven B.; Wong, Melanie; Bioorganic and Medicinal Chemistry Letters; vol. 22; 2; (2012); p. 901 – 906;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem