Synthetic Route of 54221-96-4 ,Some common heterocyclic compound, 54221-96-4, molecular formula is C7H7NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: To a solution of 6-methoxy-2-pyridinecarboxaldehyde (1.0 eq) in THF (0.05 M) was added dropwise ArMgBr (1.0 M in Et2O, 1.2 eq) at ?78 °C. After stirring at ?78 °C for 1 h, the reaction mixture was quenched by 1 N HCl and extracted with EtOAc. A combined organic layer was washed with brine, dried over MgSO4 and concentrated in vacuo. The residue was purified by flash column chromatography (EtOAc/hexanes).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 54221-96-4, 6-Methoxypicolinaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Fei, Xiang; Yuan, Yue; Lee, Young-Mi; Jeong, Kwang Won; Seo, Seung-Yong; Bulletin of the Korean Chemical Society; vol. 35; 8; (2014); p. 2547 – 2550;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem