Application of 88912-27-0, Adding some certain compound to certain chemical reactions, such as: 88912-27-0, name is 3-Chloroisonicotinic acid,molecular formula is C6H4ClNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 88912-27-0.
Reference Production Example 31A mixture of 0.60 g of 2-amino-4-(trifluoromethylthio)phenol, 0.45 g of 3- chloroisonicotinic acid, 0.71 g of WSC and 6 ml of pyridine was stirred while heating at 80C for three hours. The reaction mixture was cooled to room temperature, and then water was added to the reaction mixture, followed by extraction with ethyl acetate three times. The combined organic layers were washed with water and a saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to give 0.63 g of 3 -chloro-N- [2-hydroxy-5 -(trifluoromethylthio)pheny 1] isonicotinamide.1H-NMR (DMSO-de) delta: 10.89 (br s, IH), 10.14 (br s, IH), 8.74 (s, IH), 8.63 (d, J=4.8 Hz, IH), 8.31 (d, J=2.2 Hz, IH), 7.63 (d, J=4.8 Hz, IH), 7.39 (dd, J=8.5, 2.2 Hz, IH), 7.03 (d, J=8.5 Hz, IH)
According to the analysis of related databases, 88912-27-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; OTSUKI, Junko; WO2011/40629; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem