Related Products of 107504-08-5, Adding some certain compound to certain chemical reactions, such as: 107504-08-5, name is 5-Fluoro-2-picolinic acid,molecular formula is C6H4FNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 107504-08-5.
5-Fluoro-2-pyridinecarboxylic acid (0.10 mg, 0.68 mmol) was added to a solution of 4- (4,6-dimethoxy-l,3,5-triazin-2-yl)-4-methylmo holinium chloride (205 mg, 0.74 mmol) in MeOH (3 mL). The mixture was stirred at room temperature for 5 minutes. The mixture was cooled to 0 C and a solution of (R)-6-(5-amino-2-fluoro-phenyl)-6- methyl-5,6-dihydro-imidazo[l,2-a]pyrazin-8-ylamine (160 mg, 0.62 mmol) in MeOH (3 mL) was added. The mixture was warmed to room temperature and stirred for 18 hours. The mixture was treated with sat. Na2C03 and water and extracted with DCM. The organic layer was separated, dried (Na2S04), filtered and concentrated in vacuo. The crude product was purified by flash column chromatography (silica; 7N H3 in MeOH in DCM 0/100 to 3/97). The desired fractions were collected and the solvents evaporated in vacuo. The residue was triturated with diethyl ether, filtered and dried in vacuo to yield (R)-5-fluoro-pyridine-2-carboxylic acid [3-(8-amino-6-methyl-5,6- dihydro-imidazo[l,2-a]pyrazin-6-yl)-4-fluoro-phenyl]-amide (0.088 g, 37% yield) as a white solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 107504-08-5, 5-Fluoro-2-picolinic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; TRABANCO-SUAREZ, Andres, Avelino; DELGADO-JIMENEZ, Francisca; VEGA RAMIRO, Juan, Antonio; TRESADERN, Gary, John; GIJSEN, Henricus, Jacobus, Maria; OEHLRICH, Daniel; WO2012/85038; (2012); A1;,
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