Synthetic Route of 5470-17-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5470-17-7, name is 3-Bromo-2-chloro-5-nitropyridine, molecular formula is C5H2BrClN2O2, molecular weight is 237.44, as common compound, the synthetic route is as follows.
Step 1: 3-bromo-2-(2-methoxyethoxy)-5-nitropyridine (Intermediate 15)To a stirred solution of S-bromo-l-chloro-S-nitropyridine (1.5 g, 6.32 mmol) and 2- methoxyethanol (0.961 g, 12.63 mmol) in DMF (10 mL) , potassium carbonate (1.746 g, 12.63 mmol) was added portion wise and the mixture was stirred at 60 0C for 5 hr. Reaction mixture was then cooled to RT, diluted with ethyl acetate (150ml), washed successively with water and then brine, organic layer was collected, dried over sodium sulfate and concentrated to give crude 3-bromo-2-(2-methoxyethoxy)-5-nitropyridine (1.500 g, 86 %) as brown solid. MS (ES+): 277.9 for C8H9BrN2O4
The chemical industry reduces the impact on the environment during synthesis 5470-17-7, I believe this compound will play a more active role in future production and life.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/147431; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem