Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 86873-60-1, name is 5-Chloro-2-picolinic acid. This compound has unique chemical properties. The synthetic route is as follows. Safety of 5-Chloro-2-picolinic acid
B. 5-Chloropyridine-2-carbonyl chloride To a dry 250 mL round-bottom flask equipped with magnetic stirrer and reflux condenser was charged 5 g of 5-chloropyridine-2-carboxylic acid (0.0317 mol), 100 mL methylene chloride, and 5 drops of DMF as a catalyst. Some of the solid did not dissolve. Thionyl chloride (10 mL; 0.137 mol) was added in one portion, and the reaction was refluxed for a total of 7 hours. After cooling, the reaction was stripped to dryness and 5.1 g of a white solid was isolated. The NMR data is as follows: 300 MHz 1H NMR (CDCl3, TMS=0 ppm) 1.25 (t, 3H); 1.48 (s, 18H); 2.05 (d, 2H); 3.65 (t, 1H); 4.15 (q, 2H). The sample was stored in the refrigerator and had 59% isolated yield. The sample was used without additional purification and had 91% isolated yield.
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Reference:
Patent; DOW AGROSCIENCES LLC; US2009/253708; (2009); A1;,
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