Related Products of 116922-60-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.116922-60-2, name is 3-Bromo-4-fluoropyridine, molecular formula is C5H3BrFN, molecular weight is 175.9864, as common compound, the synthetic route is as follows.
2-(3-Bromo-4-fluorophenyl)-4,6-diphenyl-1 ,3,5-triazine E2 (1.0 equivalents), bis- (pinacolato)diboron, (1 .5 equivalents, CAS: 73183-34-3), tris(dibenzylideneacetone)dipalladium(0) Pd2(dba)3 (0.02 equivalents, CAS: 51364-51 -3), X- Phos (0.04 equivalents, CAS 564483-18-7) and potassium acetate (KOAc, 3.0 equivalents) are stirred under nitrogen atmosphere in dry toluene at 1 10 C for 16 h. After that time, 3- bromo-4-fluoropyridine (1 .0 equivalents, CAS 1 16922-60-2), K3P04 (aq) (3 equivalents) and extra portion of tris(dibenzylideneacetone)dipalladium(0) (0.02 equivalents, CAS: 51364-51 -3) and X-Phos (0.04 equivalents CAS 564483-18-7) are added to the hot reaction mixture. The reaction mixture is stirred at 1 10 C for 16 h. After cooling down to room temperature (RT) the reaction mixture is extracted with ethyl acetate/brine. The organic phases are collected, washed with brine and dried over MgSC . The organic solvent is removed, the crude product Z2 is purified by chromatography and obtained as a white solid (yield: 86 %).
The chemical industry reduces the impact on the environment during synthesis 116922-60-2, I believe this compound will play a more active role in future production and life.
Reference:
Patent; CYNORA GMBH; SZAFRANOWSKA, Barbara; (135 pag.)WO2019/2355; (2019); A1;,
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