Electric Literature of 55304-73-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.55304-73-9, name is 2,6-Dichloro-3-formylpyridine, molecular formula is C6H3Cl2NO, molecular weight is 176, as common compound, the synthetic route is as follows.
Example 27 c. 2-((2,6-dichloropyridin-3-yl)methylamino)-l-(l,3-dimethyl-lH- pyrazol-5-yl)ethanol2,6-Dichloronicotinaldehyde (0.964 g, 5.48 mmol), 2-amino-l -(1,3 -dimethyl- lH-pyrazol- 5-yl)ethanol (0.810 g, 5.22 mmol) and acetic acid (0.149 ml, 2.61 mmol) in methanol (10 mL) was stirred at room temperature for 20 minutes. Methanol (15 mL) was added and cooled to 00C. Sodium cyanoborohydride (0.394 g, 6.26 mmol) was added and the reaction mixture was stirred at 00C for 10 minutes. The solvent was evaporated and the residue was partitioned between dichloromethane and sat. NaHCO3 (aq). The water layer was extracted twice with dichloromethane and the combined organic layer was dried (MgSO4) and concentrated. The crude product was purified by silica column chromatography using a gradient of methanol (0 to 5%) in dichloromethane giving 1.5O g of the title compound (91 % Yield). 1H NMR (500 MHz, DMSO-J6) delta ppm 7.99 (dd, 1 H), 7.52 – 7.63 (m, 1 H), 5.90 (s, 1 H), 5.37 (dt, 1 H), 4.63 – 4.76 (m, 1 H), 3.76 – 3.86 (m, 2 H), 3.65 – 3.75 (m, 3 H), 3.17 (dt, 1 H), 2.69 – 2.87 (m, 2 H), 2.01 – 2.16 (m, 3 H). MS m/z 315, 317, 319 [M+H] +.
Statistics shows that 55304-73-9 is playing an increasingly important role. we look forward to future research findings about 2,6-Dichloro-3-formylpyridine.
Reference:
Patent; ASTRAZENECA AB; LO-ALFREDSSON, Yvonne; PAULSEN, Kim; RAKOS, Laszlo; ROTTICCI, Didier; WALDMAN, Magnus; WO2010/132015; (2010); A1;,
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