Reference of 72990-37-5 ,Some common heterocyclic compound, 72990-37-5, molecular formula is C6H4ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Reference Production Example 4 To a mixture of 1.53 g of 3-chloroisonicotinaldehyde and 5 ml of ethanol was gradually added 0.40 g of sodium borohydride under ice-cooling, and the mixture was stirred under ice-cooling for 1 hour, and subsequently at room temperature for 1 hour. Saturated brine was added to the reaction mixture, and the mixture was extracted twice with ethyl acetate. The organic layers were combined and dried over magnesium sulfate. The resulting mixture was concentrated under reduced pressure to obtain 1.40 g of (3-chloropyridin-4-yl)methanol. 1H-NMR (CDCl3) delta: 8.54-8.49 (m, 2H), 7.55-7.51 (m, 1H), 4.83 (d, J=4.4 Hz, 2H), 2.34-2.29 (br m, 1H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,72990-37-5, its application will become more common.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Iwakoshi, Mitsuhiko; Takyo, Hayato; US2013/90353; (2013); A1;,
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