Related Products of 626-64-2 , The common heterocyclic compound, 626-64-2, name is Pyridin-4-ol, molecular formula is C5H5NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
4-Hydroxy pyridine (0.68g, 7.20mmol), 3,5-difluorobenzonitrile (0.5g, 3.60mmol), K2CO3 (1.73g, 12.6mmol) and DMF (15ml) were taken in a 50ml round bottom flask. The mixture was stirred constantly at 80C (Scheme 1). After 48h, heating was stopped and the reaction mixture was allowed to cool down at room temperature. After that, the mixture was poured into ice-cold water to obtain a white solid precipitate. It was filtered and air dried. Yield: 0.96g, (92%). SI-MS: [M+H], m/z: 290.0934 (100%) (calcd for C17H11N3O2, 289.0851) (Fig. S1). Anal. calcd. for C17H11N3O2: C, 70.59; H, 3.80; N, 14.53%. Found: C, 70.61; H, 3.82; N, 14.6% IR (cm-1, KBr pellet): 3426 (m), 3044 (m), 2943 (m) 2245 (m), 1651 (s), 1599 (s), 1443 (s), 1349 (s), 1248 (s), 1199 (s), 1090 (m), 892 (m), 843 (s), 690 (m), 557(m), 496 (m) (Fig. S2).
The synthetic route of 626-64-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Agarwal, Rashmi A.; De, Dinesh; Polyhedron; vol. 185; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem