The origin of a common compound about

Application of 866546-07-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 866546-07-8, name is 5-Chloro-1H-pyrrolo[2,3-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

Example 18: Synthesis of 5-chloro-3-2-chIoro-5-fluoro-4-[2-(2-methoxy-ethoxy)-ethoxy]-benzyl- lH-pyrrolo[2,3-b]pyridine P-2155.[0192] 5-Chloro-3-2-chloro-5-fluoro-4-[2-(2-methoxy-ethoxy)-ethoxy]-benzyl-lH-pyrrolo[2,3- b]pyridine P-2155 was synthesized in 2 steps from 5-Chloro-lH-pyrrolo[2,3-b]pyridine 4 as shown in Scheme 40.Scheme 40 Step 1 – Preparation of2-chloro-5-fluoro-4-[2-(2-methoxy-ethoxy)-ethoxy]-phenyl-(5-chloro-lH- pyrrolo[2,3-b]pyridiotan-3-yl)-methanol (126).[0193] To 5-chloro-l H-pyrrolo[2,3-b]pyndine (4. 74.1 mg, 0 49 mmol) in methanol (30.0 mL), 2- chloro-5-fluoro-4-[2-(2-methoxy-ethoxy)-ethoxy]-benzaldehyde (121, 150.0 mg, 0.54 mmol, prepared as described in Example 14) and potassium hydroxide (574 0 mg, 10.23 mmol) were added under an atmosphere of nitrogen. The reaction was stirred at room temperature overnight The reaction was poured into water and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and filtered The filtrate was concentrated and purified by silica gel column chromatography eluting with 20% ethyl acetate in hexane to give the desired compound (126, O H g, 52.7%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 866546-07-8, 5-Chloro-1H-pyrrolo[2,3-b]pyridine.

Reference:
Patent; PLEXXIKON, INC.; WO2008/80001; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem