Related Products of 6969-71-7 ,Some common heterocyclic compound, 6969-71-7, molecular formula is C6H5N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To the commercially available [112,4]triazolo[4,3-a]pyridin-3(2H)-one (27 mg, 0.20 mmol) and 18-crown-6 ether (55 mg, 0.21 mmol) in anhydrous 1 ,4-dioxan (1 ml.) was added a 1 M solution of potassium te/t-butoxide in tetrahydrofuran (210 mul_, 0.21 mmol) . The mixture was stirred at room temperature for 15 minutes and then 1 ml_ of a solution of 3,4-dichloro-N-[5-chloro-2-(chloromethyl)phenyl]benzenesulfonamide (655 mg, 1.7 mmol) in anhydrous 1 ,4-dioxane (17 mL) was added. The mixture was heated at 60 0C for 15 hours and then left to cool to room temperature. The solvent was removed under reduced pressure and the residue dissolved in dimethyl sulphoxide (0.5 mL) and then purified by mass directed autoprep to give 3,4-dichloro-N-{5-chloro-2-[(3- oxo[1 ,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)methyl]phenyl}benzenesulfonamide as a white solid (6.6mg). HPLC Rt = 3.23 minutes; m/z [M+H]+ = 483. 1H NMR (d6-DMSO) delta 7.85 (m, 3H), 7.63 (d, 1 H), 7.28 (d, 1 H), 7.24 (t, 1 H), 7.17 (d, 1 H), 7.09 (d, 1 H), 6.99 (s, 1 H), 6.63 (t, 1 H)1 5.00 (S1 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6969-71-7, its application will become more common.
Reference:
Patent; GLAXO GROUP LIMTED; WO2007/14054; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem