In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6969-71-7, name is [1,2,4]Triazolo[4,3-a]pyridin-3(2H)-one, the common compound, a new synthetic route is introduced below. name: [1,2,4]Triazolo[4,3-a]pyridin-3(2H)-one
Firstly, 1.35 g (10 mmol) of 1,2,4-triazolo[4,3-a]pyridin-3-(2H)-one (1), 2.5 cm3 (26 mmol) of1-bromo-3-chloropropane (2a), 322 mg (1 mmol) of TBAB, 8.28 g (60 mmol) of K2CO3, and 5 cm3 ofacetonitrile were placed in a conical flask. The reactions were carried out under microwave radiation(Samsung M182DN; 300 W) for 50 s. After this time, 2.3 g (10 mmol) of 1-(3-chlorophenyl)piperazine hydrochloride (4) and 5 cm3 of acetonitrile were added to the reaction mixture. Reactions were carriedout in the presence of microwave radiation for another 90 s. The progress of the reaction was monitoredby TLC (eluent chloroform-methanol 9:1). After the reaction, 50 cm3 of water was added and theresulting product was filtered o on a Buechner funnel. Yield (Samsung M182DN; 300 W) 31%, yield(CEM Discover SP reactor; 100 W) 71%.
The synthetic route of 6969-71-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Jaskowska, Jolanta; Zar eba, Przemys?aw; Sliwa, Pawe?; Pindelska, Edyta; Sata?a, Grzegorz; Majka, Zbigniew; Molecules; vol. 24; 8; (2019);,
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