The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 70158-59-7, name is 2,5-Dichloro-3-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 2,5-Dichloro-3-(trifluoromethyl)pyridine
Step 9 Methyl 4-{[3-chloro-5-(trifluoromethyl)-2-pyridyl]oxy}-5,8-dimethyl-1,1-dioxo-1,2,3,4-tetrahydro-1lambda6-thiochromene-6-carboxylate 0.48 g (1.7 mmol) of methyl 5,8-dimethyl-4-hydroxy-1,1-dioxo-1,2,3,4-tetrahydro-1lambda6-thiochromene-6-carboxylate and 0.4 g (1.9 mmol) of 2,5-dichloro-3-(trifluoromethyl)pyridine were dissolved in 20 ml of tetrahydrofuran and subsequently admixed with 0.21 g (1.9 mmol) of potassium tert-butoxide. The mixture was stirred for 3 h and subsequently concentrated using a rotary evaporator. The residue was taken up in 100 ml of ethyl acetate, washed with sat. NaCl solution (2*20 ml), dried over MgSO4 and concentrated using a rotary evaporator. The residue was purified by chromatography (silica gel, ethyl acetate: heptane=1:3). Yield: 0.64 g (80% of theory); yellow crystals; Rt=0.71 (silica gel/ethyl acetate); 1H NMR (CDCl3): delta 2.35 (s, 3H), 2.8 (m, 2H), 2.8 (s, 3H), 3.25 (s, 1H), 3.8 (m, 1H), 3.9 (s, 3H), 6.6 (m, 1H), 7.7 (s, 1H), 7.95 (m, 1H), 8.4 (m, 1H).
With the rapid development of chemical substances, we look forward to future research findings about 70158-59-7.
Reference:
Patent; Hoechst Schering AgrEvo GmbH; US6297196; (2001); B1;,
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