Adding a certain compound to certain chemical reactions, such as: 4487-59-6, 2-Bromo-5-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2-Bromo-5-nitropyridine, blongs to pyridine-derivatives compound. name: 2-Bromo-5-nitropyridine
Example 3 5-Nitropyridine-2-carbonitrile, a Compound of Formula 1 in which C Comprises 5-nitropyridin-2-yl and R8 is –CN A mixture comprising 2-bromo-5-nitropyridine (5.6 g, 27.7 mmol), cuprous cyanide (2.5 g, 27.4 mmol) and DMF (5 mL) was heated at 105 C. for 2.5 hours, cooled and diluted with methylene chloride (200 mL). The mixture was stirred 20 minutes, filtered and concentrated under reduced pressure. The residue was dissolved in methylene chloride and the solution was washed sequentially with 2N sodium hydroxide (150 mL), 7M ammonium hydroxide (150 mL) and water (150 mL), dried (MgSO4), filtered and concentrated under reduced pressure to provide 5-nitropyridine-2-carbonitrile (3.14 g, 21 mmol) as a yellow oil. 1 H-NMR (300 Mhz, DMSO-d6): 8.4 (d, 1H), 8.8 (d, 1H), 9.5 (s, 1H); MS (EI); Calculated for C6 H3 N3 O2, 149.1, Found (MH+): 149.
The synthetic route of 4487-59-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Axys Pharmaceuticals, Inc.; US6150379; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem