Synthetic Route of 620-08-6 , The common heterocyclic compound, 620-08-6, name is 4-Methoxypyridine, molecular formula is C6H7NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: An test tube was charged with acetophenone (1a, 0.6 mmol, 72.1 mg), pyridine (2a, 0.6 mmol, 47.5 mg), methyl acrylate (3a, 0.3 mmol, 25.8 mg), K2CO3 (2.4 mmol, 331.7 mg) , I2 (1.2 mmol, 304.6 mg), CuI (0.06 mmol, 11.4 mg) and 1 mL DMF. The reaction mixture was stirred at 90 C for 16 h. After completion of the reaction, the reaction mixture was diluted with EtOAc, and washed with 10% Na2S2O3 solution (50 mL). Then the mixture was extracted with EtOAc (20 mL×3), and the combined organic layers were dried over Na2SO4, filtered, and concentrated invacuo. The remaining crude product was then purified through column chromatography using silica gel (EtOAc/petroleum ether = 1/10) to afford 4a as a yellow solid in 66% yield.
The synthetic route of 620-08-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Fang, Youlai; He, Lisheng; Pan, Weidong; Yang, Yuzhu; Tetrahedron; vol. 75; 27; (2019); p. 3767 – 3771;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem