Application of 116632-24-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 116632-24-7, name is 2-Amino-4,6-dichloropyridine. A new synthetic method of this compound is introduced below.
Reference Example 4 6-chloro-4-fluoropyridin-2-amine (0375) 7.46 g (49.11 mmol) of cesium fluoride were added at room temperature to a mixed solution of 2.00 g (12.27 mmol) of 4,6-dichloropyridin-2-amine and 30 ml dimethyl sulfoxide. After completion of the addition, said reaction mixture liquid was stirred for 12 hours at 170 C. After completion of the stirring, the reaction was stopped by addition of 100 ml of water, and said reaction liquid was extracted with ethyl acetate (2×300 ml). The organic layer obtained was dried with anhydrous sodium sulfate, and the solvent distilled off under reduced pressure. The residue obtained was purified by silica gel chromatography (n-hexane:ethyl acetate=9:1 to 5:5), and 95 mg of the desired compound were obtained as a white solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,116632-24-7, its application will become more common.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; NAKAYA, Yoshihiko; MASUZAWA, Yoshihide; FURUHASHI, Takamasa; MIYAKADO, Yuuki; HOTTA, Hiroyasu; INABA, Masamitsu; (76 pag.)US2016/221998; (2016); A1;,
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