Reference of 183208-35-7 ,Some common heterocyclic compound, 183208-35-7, molecular formula is C7H5BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step 1: (0558) To a solution containing compound 6 (2.0 g, 10.15 mmol) dissolved in N,N-dimethylformamide (78.93 mL, 1015.05 mmol) was added 1-iodopyrrolidine-2,5-dione (2.28 g, 10.15 mmol) and the solution was allowed to stir at room temperature for 2 hours. Upon completion, the reaction mixture was poured into a saturated aqueous sodium thiosulfate solution and extracted with ethyl acetate (3×150 mL). The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate, filtered, and then evaporated to dryness to give 3.15 grams of compound 7 in about 95% purity.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,183208-35-7, its application will become more common.
Reference:
Patent; Plexxikon Inc.; Lin, Jack; Pham, Phuongly; Buell, John; Dong, Ken; Ibrahim, Prabha; Spevak, Wayne; Tsang, Garson; Wu, Guoxian; Zhang, Ying; (183 pag.)US2016/326162; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem