Reference of 1235342-53-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1235342-53-6, name is 3-(Bromomethyl)-5-methylpyridine hydrobromide. A new synthetic method of this compound is introduced below.
An inert atmosphere N2 was passed through a 1 L three-necked round bottom flask and held.3-Bromomethyl-5-methylpyridine hydrobromide (Compound A, 20 g, 74.92 mmol) was added.Dichloromethane (200ml) and water (40g),Then, sodium hydrogencarbonate (27.1 g, 322.58 mmol) was added dropwise with stirring at 0 C.Aqueous solution (40ml)And m-CPBA (37.1g, 214.99mmol)A solution of dichloromethane (200 ml).Stir at room temperature for 2 hours.The resulting solution was extracted with 5 x 200 ml of dichloromethane.Combine the organic layers,Dry with anhydrous sodium sulfate,Concentrate in vacuo.The residue was applied to a silica gel column eluting with dichloromethane/methanol.Get 7.5g (50%)Compound B3-bromomethane-5-methylpyridine-N-oxide pale yellow solid,The test results are shown in Figure 1.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1235342-53-6, 3-(Bromomethyl)-5-methylpyridine hydrobromide, and friends who are interested can also refer to it.
Reference:
Patent; Hangzhou Aoyi Baoling Pharmaceutical Co., Ltd.; Fang Yuan; Jin Yukun; Gong Wen; Li Fugao; Sun Xiaoyan; Ling Jue; Yu Yingmin; (15 pag.)CN109678841; (2019); A;,
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