Adding a certain compound to certain chemical reactions, such as: 603305-89-1, 7-Bromothieno[3,2-b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 603305-89-1, blongs to pyridine-derivatives compound. Recommanded Product: 603305-89-1
General procedure: A dry Schlenk tube was charged under Ar with dry toluene (3 mL), the fluoro or methoxyanilines (1.1 equiv.), Pd(OAc)2 (6 mol%), BINAP (8 mol%), Cs2CO3 (2 equiv.) and compound 1. The mixture was heated with stirring under Ar at 100 C for 2 h. After cooling water (5 mL) and ethyl acetate (5 mL) were added. The phases were separated and the aqueous phase was extracted with more ethyl acetate (2 × 5 mL). The organic phase was dried (MgSO4) and filtered. Removal of the solvent gave a solid which was submitted to a dry flash in silica using ether or AcOEt and a solid was obtained.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,603305-89-1, its application will become more common.
Reference:
Article; Queiroz, Maria-Joao R.P.; Peixoto, Daniela; Calhelha, Ricardo C.; Soares, Pedro; Dos Santos, Tiago; Lima, Raquel T.; Campos, Joana F.; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Vasconcelos, M. Helena; European Journal of Medicinal Chemistry; vol. 69; (2013); p. 855 – 862;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem