Synthetic Route of 1446507-38-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1446507-38-5, name is 6-(6-(Trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione. A new synthetic method of this compound is introduced below.
POCl3 (175.0 mL) is charged into the reaction vessel at 20-35 C., and 6-(6-trifluoromethyl-pyridin-2-yl)-1H-1,3,5-triazine-2,4-dione (35.0 g, 0.1355 mol) was added in portions at below 50 C. The reaction mixture was de-gassed 5-20 minutes by purging with N2 gas. Phosphorous pentachloride (112.86 g, 0.542 mol) was added while stirring at below 50 C., the resulting slurry was heated to reflux (105-110 C.) and maintained for 3-4 h. The reaction mixture was cooled to 50-55 C., concentrated at below 55 C. then cooled to 20-30 C. The reaction mixture was rinsed with ethyl acetate and the ethyl acetate layer was slowly added to cold water (temperature 5 C.) while stirring and maintaining the temperature below 10 C. The mixture was stirred 3-5 minutes at a temperature between 10 to 20 C. and the ethyl acetate layer was collected. The reaction mixture was rinsed with sodium bicarbonate solution and dried over anhydrous sodium sulphate. The material was dried 2-3 h under vacuum at below 45 C. to provide 2, 4-dichloro-6-(6-trifluoromethyl-pyridin-2-yl)-1, 3, 5-triazine.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1446507-38-5, 6-(6-(Trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.
Reference:
Patent; Agios Pharmaceuticals, Inc.; Agresta, Samuel V.; (34 pag.)US2018/311249; (2018); A1;,
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