Adding a certain compound to certain chemical reactions, such as: 38749-79-0, 3-Bromo-2-methylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H6BrN, blongs to pyridine-derivatives compound. HPLC of Formula: C6H6BrN
Lithium hexamethyldisilazane (436 mL, 0.44 mmol, 1 M solution in hexanes) was dissolved in diethyl ether (1 L). Compound 26, 3-bromo-2-methylpyridine, (25.0 g, 0.14 mmol) was added. The solution was stuffed for 1 h. Diethyl carbonate (26.0 mL, 0.22 mol) was added and the solution was stirred overnight. The reaction solution was washed three times with half-saturated aqueous sodium chloride (3 x 250 mL) and dried with magnesium sulfate. The solvent was evaporated and the reminder was dissolved in hexanes (200 mL). The solution was filtered through silica pad (10 g), the pad was rinsed with additional hexanes (100 mL) and the solvent was evaporated. The remaining oil was stirred in high vacuum for 1 hour till there were no further bubbles visible. The product was a yellow liquid(37.7 g). LCMS: [M + Hj = 244.1.
The synthetic route of 38749-79-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KALA PHARMACEUTICALS, INC.; KIM, Jinsoo; NGUYEN, Minh N.; ENLOW, Elizabeth; ONG, Winston Z.; NOWAK, Pawel W.; FEUTRILL, John T.; WO2014/201127; (2014); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem