Related Products of 98198-48-2, Adding some certain compound to certain chemical reactions, such as: 98198-48-2, name is 2-Amino-5-bromo-4-methylpyridine,molecular formula is C6H7BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 98198-48-2.
General procedure: Under inert atmosphere, a mixture of halide F, D, K or P (1.0 equiv.), boronic acid derivative R1-M G or J (1.5 equiv.), PdCI2(dppf)2 (0.1 equiv.) and aqueous Na2CO3 (1.2 M – 3.0 equiv.) in DMF (C=0.1 molL-1) was submitted to microwave irradiation (150C, 15 min, P< 70W). The reaction mixture was hydrolysed, and then extracted with EtOAc twice. The organic layers were combined, washed with brine, dried over MgSO4, concentrated and purified to afford the product. To a solution or suspension of the free base in MeOH, HCl in MeOH (1.25N, 5 equiv.) was added. The mixture was vigorously stirred, then concentrated. The residue was taken in Et2O. The resulting solid was collected, washed with Et2O and dried at 50C under reduced pressure with P2O5.
According to the analysis of related databases, 98198-48-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; DOMAIN THERAPEUTICS; MAYER, Stanislas; SCHANN, Stephan; WO2013/174822; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem