The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 133627-45-9, name is 2-Chloro-4-methylpyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 133627-45-9
(1) Add 37.0 g of sodium metal (Na) to 383 ml of methanol (MeOH) in 1L three-necked flask in portions, and add hydrogen over about 50 min to control the release of hydrogen. When Na is clear, dissolve 38.3 g of compound 12- Methyl-3-aminopyridine and cuprous iodide were all placed in a 1 L autoclave and heated to 110 C. overnight (about 14 h); on the next day, the reaction was complete by TLC and the solvent was decanted and ice-dissolved. 500 mL of MTBE Ether), the organic phase was dried and the solvent was decanted to give 229.4 g of product in 78.7% yield.TLC information: Raw Rf = 0.4, Product Rf = 0.7.Developing solvent: petroleum ether: ethyl acetate (PE: EA) = 10: 1.
With the rapid development of chemical substances, we look forward to future research findings about 133627-45-9.
Reference:
Patent; Si Fenke Si Pharmaceutical Research And Development (Tianjin) Co., Ltd.; Yao Qingjia; Wu Simin; Xu Yangjun; (7 pag.)CN104230811; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem