With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.802325-29-7, name is (5-Fluoropyridin-2-yl)methanol, molecular formula is C6H6FNO, molecular weight is 127.12, as common compound, the synthetic route is as follows.Quality Control of (5-Fluoropyridin-2-yl)methanol
To a stirred solution of (5-fluoropyridin-2-yl)methanol (500 mg, 3.937 mmol, commercial source: Combi-Blocks) and triethylamine (398 mg, 3.937 mmol) in /V,/V-dimethylformamide (10 ml_), mesyl chloride (451 mg, 3.937 mmol) was added at 27 C. The reaction mixture was stirred at 27 C for 2 h. Followed by the addition of sodium azide (384 mg, 5.905 mmol) at 27 C and the reaction mixture was stirred for 12 h at the same temperature. Upon completion, the reaction mixture was concentrated under reduced pressure. The crude compound was purified by column chromatography (silica gel 100-200 mesh) using 5% ethyl acetate in pet ether. The pure fractions were collected and concentrated under reduced pressure to afford 2-(azidomethyl)-5- fluoropyridine (150 mg, 25%) as a brown liquid. NMR (400 MHz, CDCI3) 5 8.46 (d, J = 2.6 Hz, 1 H), 7.47-7.40 (m, 1 H), 7.39-7.33 (m, 1 H), 4.48 (s, 2H). MS m/z [M+H]+= 153.12.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,802325-29-7, (5-Fluoropyridin-2-yl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ALEMPARTE-GALLARDO, Carlos; ENCINAS, Lourdes; ESQUIVIAS PROVENCIO, Jorge; (206 pag.)WO2019/34729; (2019); A1;,
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