Adding a certain compound to certain chemical reactions, such as: 52200-48-3, 3-Bromo-2-chloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C5H3BrClN, blongs to pyridine-derivatives compound. Computed Properties of C5H3BrClN
To a mixture of 3-bromo-2-chloropyridine (200 mg, 1 mmol) in EtOH (5 ml_) was added t- BuOK (233 mg, 2 mmol) The mixture was stirred at 80C for 12 hours. The reaction mixture was filtered and the filtrate was concentrated in vacuo to give the crude product. The residue was purified by flash chromatography on silica gel (0%~40% ethyl acetate in petroleum ether) to afford 3-bromo-2-ethoxypyridine.
The synthetic route of 52200-48-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; H. LUNDBECK A/S; KEHLER, Jan; JUHL, Karsten; MARIGO, Mauro; VITAL, Paulo, Jorge, Vieira; JESSING, Mikkel; LANGGARD, Morten; RASMUSSEN, Lars, Kyhn; CLEMENTSON, Carl, Martin, Sebastian; (270 pag.)WO2018/7249; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem