Application of 54221-96-4 ,Some common heterocyclic compound, 54221-96-4, molecular formula is C7H7NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
6-Methoxy-2-pyridinecarboxaldehyde (1.0 mL, 8.31 mmol) and 2-naphthylamine (1.19 g,8.33 mmol) were dissolved in 25 mL of anhydrous methanol and the resulting mixture washeated at reflux temperature for 6 h. The solvent was removed under reduced pressure togive brown solids. Yield: 1.58 g (72percent). Anal. Calcd (percent) for C17H14N2O (M = 262.31 g mol?1): C,77.84; H, 5.38; N, 10.68. Found: C, 77.88; H, 5.43; N, 10.71. FT-IR (KBr, cm?1): 3439(w), 3051(w),2976(w), 2840(w), 1632(m), 1586(s), 1569(m), 1508(w), 1467(s), 1438(m), 1413(w), 1350(w),1334(m), 1321(m), 1267(s), 1229(w), 1208(w), 1167(w), 1151(m), 1120(w), 1078(w), 1032(m),985(w), 961(w), 911(w), 887(w), 860(s), 824(m), 808(s), 750(s), 734(w), 666(w), 626(w), 603(w),523(w), 504(w), 478(w), 430(w). 1H NMR (400 MHz, CDCl3): delta 8.63 (s, 1H, CH = N), 7.52?7.87(m, 7H, Naphthalene-H), 6.84?7.02 (m, 3H, Py-H3,4,5), 4.03 (s, 3H, ?OCH3) ppm.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,54221-96-4, its application will become more common.
Reference:
Article; Dong, Yu-Wei; Wang, Ping; Fan, Rui-Qing; Chen, Wei; Wang, A-Ni; Yang, Yu-Lin; Journal of Coordination Chemistry; vol. 70; 11; (2017); p. 1953 – 1972;,
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