Reference of 78607-36-0, Adding some certain compound to certain chemical reactions, such as: 78607-36-0, name is 2-Chloro-3-iodopyridine,molecular formula is C5H3ClIN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 78607-36-0.
A mixture of 2-chloro-3-iodopyridine (400 mg , 1.67 mmol ), 2-methylpiperazine (200 mg, 2.0 mmol), sodium tert-butoxide (224 mg, 2.3 mmol), 9,9-dimethyl-4,5-bis(diphenyl- phosphino)Xanthen (48 mg, 0.08 mmol) and tris(dibenzylideneacetone) palladium (38 mg, 0.04 mmol) in toluene (6 mL) was heated at 110C for 18 hours. The mixture was poured out into water, extracted with EtOAc, the mixture was filtered through a short pad of Celite, the organic layer was separated, washed with water and brine, dried (MgS04), evaporated till dryness and the residue was carried out by flash chromatography over silica gel (grace, 40 g,CH2Cl2/MeOH/NH4OH 95/5/0.5) The pure fractions were collected and evaporated to dryness to afford 155 mg (44%) of intermediate (8).
According to the analysis of related databases, 78607-36-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; JANSSEN R&D IRELAND; GUILLEMONT, Jerome Emile Georges; LANCOIS, David Francis Alain; MOTTE, Magali Madeleine Simone; LARDEAU, Delphine Yvonne Raymonde; BALEMANS, Wendy Mia Albert; ROYMANS, Dirk Andre Emmy; WO2015/14836; (2015); A1;,
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