Reference of 16498-81-0 , The common heterocyclic compound, 16498-81-0, name is 2-Methoxynicotinic acid, molecular formula is C7H7NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Add 100 ml of water and 20 g of 2-methoxynicotinic acid to a 250 ml three-necked flask, then add 32 g of NBS.After 16 hours of reaction at a temperature of 20-25 degrees, a sample was taken for HPLC detection, and the reaction was terminated when HPLC detected that the starting material was less than 2%.After the end of the reaction, the mixture was filtered, and the solid was dried to give the product 2-methoxy-5-bromonicotinic acid, weight: 26.36 g, yield 87%.
The synthetic route of 16498-81-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanghai Huichuan Bio-pharmaceutical Technology Co., Ltd.; Tang Bengang; He Weihua; (16 pag.)CN109503473; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem