As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 107504-08-5, name is 5-Fluoro-2-picolinic acid, molecular formula is C6H4FNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C6H4FNO2
General procedure: To a round-bottomed flask, 2,4-diphenylquinoline (dpq, 3.99 g,14.2 mmol), iridium trichloride hydrate (2.00 g, 5.7 mmol), deionizedwater (10 mL) and 2-ethoxyethanol (30 mL) were added sequentiallyand the mixture was stirred at 110 C overnight under a nitrogen atmosphere.After the solution was cooled to room temperature, theprecipitate was collected by filtration, washed with water and ethanol,and then dried to give a cyclometallated iridium(III) mu-chloro-bridgeddimer ([Ir(dpq)2Cl]2) in 72% yield. The dimer was directly redissolvedin CH2Cl2, and then, 2.5 equivalents fluoropicolinic acid along with amixture of methanol and triethylamine (8:1, v/v) were added. Themixed solution was stirred at room temperature under a nitrogen atmospherefor 6 h, and further distilled by vacuum. The crude productswere further purified by silica column chromatography using dichloromethane/ethyl acetate (6:1, v/v) as the eluent to give the desiredfluorinated cyclometalated iridium(III) complexes (FIr1-FIr4)
With the rapid development of chemical substances, we look forward to future research findings about 107504-08-5.
Reference:
Article; Zhang, Man; Hu, Yuan-Yuan; Pan, Miao; Tong, Bi-Hai; Wang, Song; Zhou, Hui-Dong; Shi, Peng; Zhang, Qian-Feng; Dyes and Pigments; vol. 165; (2019); p. 11 – 17;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem