Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 116387-40-7, name is Methyl 5-iodo-2-oxo-1,2-dihydropyridine-3-carboxylate. A new synthetic method of this compound is introduced below., Formula: C7H6INO3
c) Methyl 2-chloro-S-iodonicotinate. To a solution of anhydrous DMF (21.45 mL) and distilled POCl3 (26.13 mL) in anhydrous DCM (900 mL) was added methyl 2-hydroxy-5-iodonicotinate (39 g, 0.14 mol) in one portion. The mixture was stirred at room temperature for 28 hours under a N2 atmosphere. The solvent was removed under reduced pressure, and the residue was diluted with H2O. The pH of the aqueous solution was adjusted to pH = 8~9 with a saturated aqueous solution OfNaHCO3. The mixture was extracted with DCM (5 x). The combined organic layers were dried over Na2SO4 and filtered. The filtrate was evaporated under reduced pressure, and the oily residue was purified by silica gel column chromatography (1 : 10 EtOAc/hexanes) to give the title compound as a white solid.
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Reference:
Patent; AMGEN INC.; WO2008/130600; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem