Related Products of 5969-83-5 ,Some common heterocyclic compound, 5969-83-5, molecular formula is C11H8ClN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: 2-Phenylpyridine (77.5 mg, 0.5 mmol, 1 eq), RuCl3 (2.6 mg, 0.0125 mmol, 5 mol%), FeCl3. 6 H2O (108 mg, 0.4 mmol) and [BuEt3N][NTf2] (15) (0.5 mL) were added under an atmosphere of air to a 10 ml round bottom flask. The reaction was stirred for 48 h at 110 C. After completion of the reaction, it was cooled to room temperature and then ethyl acetate (1 mL) and triethylamine (1 mL) were added and the mixture was allowed to stir for 30 min. The purification was performed by flash chromatography (diethyl ether/ n-hexane = 1 : 1) to afford 2 (64 mg, 21 mmol, 83 %).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5969-83-5, 2-(4-Chlorophenyl)pyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Muntzeck, Maren; Pippert, Felix; Wilhelm, Rene; Tetrahedron; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem