Adding a certain compound to certain chemical reactions, such as: 886365-28-2, Methyl 5-bromo-2-chloroisonicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: Methyl 5-bromo-2-chloroisonicotinate, blongs to pyridine-derivatives compound. name: Methyl 5-bromo-2-chloroisonicotinate
To a mixture of methyl 5-bromo-2-chloroisonicotinate (10 g, 39.9 mmol) and Pd(Ph3P)4(4.61 g, 3.99 mmol) in THF (100 mL) was added trimethylaluminum (26.0 mL, 51.9 mmol) at 25C. The mixture was then heated to and stirred at 80 C for 6 h. Water (5 mL) was added toquench the reaction and the mixture was concentrated in vacuum. The residue was purified by flash silica gel chromatography (eluting with ethyl acetate/pet. ether gradient) to give methyl 2- chloro-5-methylisonicotinate as a colorless oil. MS: 186 (M + 1). ?HNMR (400 MHz, CDC13) 8.29 (s, 1H), 7.70 (s, 1H), 3.91 (s, 3H), 2.49 (s, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,886365-28-2, Methyl 5-bromo-2-chloroisonicotinate, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; CTXT PTY. LTD.; MACHACEK, Michelle, R.; WITTER, David, J.; REUTERSHAN, Michael Hale; ALTMAN, Michael, D.; STUPPLE, Paul Anthony; (67 pag.)WO2019/94311; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem