Application of 5470-70-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 5470-70-2 as follows.
NBS (13.0 g, 0.0728 mol) and BPO (1.6 g, 0.0066 mol) were added to a solution of methyl 6-methylnicotinate (10 g, 0.0662 moles) in CCl4 (100 ml) at room temperature TheThe reaction mixture was heated to 75 & lt; 0 & gt; C and stirred for 12 hours. After cooling, water (80 ml) was added,And extracted with ethyl acetate (200 ml x 2). The organic layer was sequentially saturated with sodium thiosulfate (80 ml)Aqueous solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column (eluent: petroleum ether / ethyl acetate = 20/1) to give methyl 6- (bromomethyl) nicotinate (5.2 g, yield 34%) as a brown solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5470-70-2, its application will become more common.
Reference:
Patent; CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; DING, ZHAO ZHONG; WU, HAO; SUN, FEI; WU, LI FANG; YANG, LING; (97 pag.)TWI558709; (2016); B;,
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