Reference of 74976-31-1 , The common heterocyclic compound, 74976-31-1, name is 6-Chloro-1H-pyrrolo[3,2-c]pyridine, molecular formula is C7H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 6-chloro-1H-pyrrolo[3,2-c]pyridine (153 mg, 1.00 mmol) in DMF (5 mL) were added PhSO2Cl (195 mg, 1.10 mmol) and Cs2CO3 (653 mg, 2.01 mmol), and the resulting mixture was stirred at 60 C. for 3 h then concentrated under reduced pressure. The residue was treated with H2O (20 mL), and the mixture was extracted with EtOAc (3*10 mL). The combined organic layers were washed with sat. aq. NaCl, dried over MgSO4, filtered and concentrated under reduced pressure to give the crude title compound as a yellow solid (290 g, 99%), which was used without further purification. MS (ES+) C13H9ClN2O2S requires: 292, found: 293 [M+H]+.
The synthetic route of 74976-31-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Board of Regents, The University of Texas System; LE, Kang; SOTH, Michael J.; JONES, Philip; CROSS, Jason Bryant; CARROLL, Christopher L.; MCAFOOS, Timothy Joseph; MANDAL, Pijus Kumar; US2019/298729; (2019); A1;,
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