Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 779345-37-8, name is 5-Fluoro-2-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 779345-37-8
To a solution of 2-bromo-4,6-dichlorophenol (2, 2.0 g, 14.0 mmol) in MeCN (20 ml), Cs2CO3 (5.50 g, 17.0 mmol) was added. After stirring at room temperature for 15 min, 5-fluoro-2-nitropyridine (12, 2.45 g, 14.0 mmol) was added dropwise and the reaction mixture was sealed for 16 h at 80 C. The reaction was concentrated in vacuo. The residue was purified by flash column chromatography [normal phase, silica gel (100-200 mesh), gradient 10% to 15% ethyl acetate in hexane] and then triturated with pentane (100 ml) to give 5-(2-bromo-4,6-dichlorophenoxy)-2-nitropyridine (13, 1.5 g, 50%) as an off-white solid. MS (ESI -ve): 363 1H-NMR (400 MHz; CDCl3): d 7.28 (d, J = 2.3 Hz, 1H), 7.52 (s, 1H), 7.64 (s, 1H), 8.22 – 8.30 (m, 2H).
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Reference:
Article; O’Brien, Alistair; Andrews, Stephen P.; Baig, Asma H.; Bortolato, Andrea; Brown, Alastair J.H.; Brown, Giles A.; Brown, Sue H.; Christopher, John A.; Congreve, Miles; Cooke, Robert M.; De Graaf, Chris; Errey, James C.; Fieldhouse, Charlotte; Jazayeri, Ali; Marshall, Fiona H.; Mason, Jonathan S.; Mobarec, Juan Carlos; Okrasa, Krzysztof; Steele, Kelly N.; Southall, Stacey M.; Teobald, Iryna; Watson, Steve P.; Weir, Malcolm; Bioorganic and Medicinal Chemistry Letters; vol. 29; 20; (2019);,
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