Adding a certain compound to certain chemical reactions, such as: 186593-43-1, 5-Amino-3-bromo-2-methylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 186593-43-1, blongs to pyridine-derivatives compound. Computed Properties of C6H7BrN2
4 – [(4-methyl-piperazin-1-yl) methyl] -3- (trifluoromethyl) benzoicacid (297 mg, 0.754 mmol), 2- (7- aza-benzotriazole ) -Nu, Nu, Nu ‘, Nu’-tetramethyluronium hexafluorophosphate (317 mg, 0.834 mmol) and N, N-diisopropylethylamine (0.17 mL, 1.043 mmol) was dissolved in N, N -dimethylformamide (5 mL) in. This mixture was added thereto and stirred atroom temperature for half an hour 5- bromo-6-methyl-3-aminopyridine (130 mg,0.695 mmol), stirred at room temperature continued overnight.After completionof the reaction by TLC, cooled to room temperature, water was added thereto,extracted with ethyl acetate, the organic phase was dried over anhydrous sodiumsulfate, filtered, and the solvent was evaporated to dryness, the residue waspurified by silica gel column chromatography to give N- (5- bromo – 6-methyl -pyridin-3-yl) -4- (4-methyl – piperazin-1-ylmethyl) -3-trifluoromethyl – benzamide(yellow solid, 80 mg)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,186593-43-1, its application will become more common.
Reference:
Patent; Shanghai Pharmaceuticals Holding Co.,Ltd .; WAN, HUIXIN; LI, CHUNLI; SHI, Chen; Liu, Haiyan; Li, Ping; XIA, Guangxin; HAN, Yanan; (52 pag.)CN103420977; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem