The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 175205-81-9, name is 2-Bromo-4-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C6H3BrF3N
A 5mL microwave vial flushed with Argon was charged with 2-bromo-4-(trifluoromethyl)pyridine (0.0923 mL, 0.724 mmol), 5-cyclopropyl-2-[3-ethylsulfonyl-5-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2- yl )-2-pyridyl]-3-m ethyl-6-(trifluoromethyl)im idazo[4 , 5-c]pyrid in-4-one (Step A, 0.2 g), tetrakis(triphenylphosphine) palladium(0) (0.042 g, 0.036 mmol), potassium phosphate tribasic (0.48 g, 2.17 mmol), toluene (2.9 mL) and water (2.9 mL). The mixture was then heated 30 at 110°C under microwave. The reaction mixture was diluted with water and ethyl acetate then, after separation of the phases, the aqueous phase was extracted two time with ethyl acetate. The combined organic phases were dried over sodium sulfate and concentrated under vacuum. The residue was subjected to columnchromatography over silica gel, eluting with ethyl acetate cyclohexane. The selected fractions were evaporated to yield the title compound as a white solid (0.11 g). 1H NMR (400 MHz, CDCI3) oe ppm 1.08 (m, 2H), 1.30 (m, 2H), 1.40 (t, 3 H), 3.11 (m, 1 H), 3.85(q, 2 H), 4.09 (s, 3 H), 7.20 (s, 1 H), 7.65 (d, 1 H), 8.11 (s, 1 H), 9.00 (d, 1 H), 9.11 (s, 1 H).
With the rapid development of chemical substances, we look forward to future research findings about 175205-81-9.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; JUNG, Pierre, Joseph, Marcel; EDMUNDS, Andrew; MUEHLEBACH, Michel; HALL, Roger, Graham; (106 pag.)WO2017/89190; (2017); A1;,
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