The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 17282-03-0, name is 3-Bromo-2-chloro-5-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives
Step 131.4: 3-Bromo-2-methoxy-5-methyl-pyridine To a solution of 3-bromo-2-chloro-5-methylpyridine (5 g, 24.2 mmol) in MeOH (80 mL) was added a solution of sodium methoxide 5.4M in MeOH (25 mL, 135 mmol) and the mixture was stirred at 65C for 32 h. The resulting suspension was filtered and the mother liquor was concentrated. Et20 and H20 were added and the phases were separated. The organic layer was washed with H20 and brine, dried (MgS04), filtered and concentrated. The residue was purified by flash chromatography (heptane/EtOAc: 90: 10? 0:100) to afford the title compound. tR: 1.03 min (LC-MS 2).
With the rapid development of chemical substances, we look forward to future research findings about 17282-03-0.
Reference:
Patent; NOVARTIS AG; FURET, Pascal; GUAGNANO, Vito; HOLZER, Philipp; KALLEN, Joerg; LIAO, Lv; MAH, Robert; MAO, Liang; MASUYA, Keiichi; SCHLAPBACH, Achim; STUTZ, Stefan; VAUPEL, Andrea; WO2013/111105; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem