As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 110651-92-8, name is 7-Chloro-6-nitrothieno[3,2-b]pyridine, molecular formula is C7H3ClN2O2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C7H3ClN2O2S
A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (156 mg, 0.727 mmol), [(5S)- 5-amino-5,6-dihydro-2H-pyran-2-yl]methyl acetate (129 mg, 0.754 mmol) and N,N- diisopropylethylamine (0.26 mL, 1.5 mmol) in isopropyl alcohol (1.7 mL) was heated at 90 C for 2 h. The reaction mixture was concentrated and purified with flash chromatography to give the desired product (0.21 g 83%). LCMS calculated for CisHieNsOsS (M+ H)+: m/z = 350.1 ; Found: 350.0.
With the rapid development of chemical substances, we look forward to future research findings about 110651-92-8.
Reference:
Patent; INCYTE CORPORATION; SCHERLE, Peggy A.; LIU, Xuesong; WO2015/157257; (2015); A1;,
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