Application of 500-22-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 500-22-1 as follows.
General procedure: In a round-bottomed flask equipped with a condenser and a magnetic stirrer, a mixture of aldehyde (1 mmol), 1,2-phenylenediamine (1 mmol) and Cu(II)-TDnSiO2 (10 mg, containing 0.0034 mmol Cu(II)) in EtOAc (2 mL) was stirred at 50 C. The progress of the reaction was monitored by TLC (eluent: n-hexane/EtOAc, 2:1). After completion of the reaction, the mixture was cooled to room temperature and EtOAc/EtOH (3:2, 15 mL) was added. The catalyst was separated by filtration and washed with EtOAc (10 mL). The filtrate was evaporated and the crude product was purified by recrystallization from EtOAc or EtOH to afford the pure product
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,500-22-1, its application will become more common.
Reference:
Article; Nasr-Esfahani, Mahboobeh; Mohammadpoor-Baltork, Iraj; Khosropour, Ahmad Reza; Moghadam, Majid; Mirkhani, Valiollah; Tangestaninejad, Shahram; Journal of Molecular Catalysis A: Chemical; vol. 379; (2013); p. 243 – 254;,
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